Potassium Iodide → HCID 15381110, compound

Participants

Reaction Conditions

Reaction Steps

60 g (347 mmol) of 2-bromophenol, 57.43 g (416 mmol) of potassium carbonate, 57 g (347 mmol) of potassium iodide, 600 ml of N,N-dimethylformamide and 4.34 g (416 mmol) of 3-chloro-2-butanone are introduced into a 1 liter three-necked flask equipped with a reflux condenser. The mixture is heated at 80° C. for 16 hours. 1500 ml of water are added and extraction is then carried out with ethyl acetate (3×400 ml). The organic phases are combined, washed with a molar sodium hydroxide solution (2×500 ml), dried over magnesium sulphate and concentrated. The residue is purified by chromatography on a silica column (elution solvent cyclohexane:ethyl acetate 9:1). 75.07 g (Yield: 89%) of 3-(2-bromophenoxy)-2-butanone (yellow oil) are obtained.

Provenance & Evidence