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Malonic Acid → (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)acrylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Malonic Acid | HCID 867 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 2,3-Dihydro-1,4-benzodioxine-5-carbaldehyde | HCID 2795033 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)acrylic acid | HCID 5343159 | — |
反応手順
A mixture of 2,3-dihydrobenzodioxin-5-carboxaldehyde (Morishima, et al., Eur. Pat. Appl. 309,766, Apr. 5, 1989) (9.25 g, 56.4 mmol), malonic acid (11.73 g, 112.8 mmol), pyrrolidine (1 mL), and pyridine (25 mL) was heated to reflux for 2 hr, cooled, and then poured into ice water (300 mL). The white precipitate was filtered, washed with 1N HCl, and air dried (9.83 g, 84.6%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06060506 |
| 出典データセット | uspto-grants-2000_05 |
| ORD ID | ord-04cf1a436de6409ca69f7fb1cfa8a35d |
| 出典メモ | uspto-grants-2000_05 |