Triphenylphosphine → 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene

関与物質

役割	名称	HCID	仕込み量
反応物	Triphenylphosphine	HCID 11776	—
反応物	1-Ethylpiperidin-4-ol	HCID 77056	—
反応物	Diethyl azodicarboxylate	HCID 5462977	—
反応物	2-(4-Methoxyphenyl)-3-(4-Hydroxybenzoyl)-6-Methoxybenzo[b]thiophene	HCID 9865197	—
生成物	6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene	HCID 15462162	55%

反応手順

6-Methoxy-2-(4-methoxyphenyl)-3-(4-hydroxybenzoyl)benzo[b]thiophene (1.17 g, 3.00 mmol), 4-hydroxy-1-ethylpiperidine (775 mg, 6.00 mmol), triphenylphosphine (1.57 g, 6.00 mmol), and DEAD (6.00 mmol) were converted to product by the procedure of Example 1 to give 827 mg of the title compound. Yield: 55%. MS(FD) 501(M+). EA calculated for C30H31NO4S: C, 71.83; H, 6.23; N, 2.79. Found: C, 71.61; H, 5.94; N, 2.69.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06060488
出典データセット	uspto-grants-2000_05
ORD ID	ord-19806ccf60714d8aa2b598f152d8ffc7
出典メモ	uspto-grants-2000_05