Ethanethiol → 6-Hydroxy-2-(4-Hydroxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene

Participants

Role	Name	HCID	Charge
Reactant	Ethanethiol	HCID 6343	—
Reactant	Aluminum(III) Chloride	HCID 6451240	—
Reactant	6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene	HCID 15462162	—
Product	6-Hydroxy-2-(4-Hydroxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene	HCID 9847697	72%

Reaction Steps

6-Methoxy-2-(4-methoxyphenyl)-3-(4-[1-ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene (502 mg, 1.00 mmol), ethane thiol (5.00 mmol), and aluminum chloride (800 mg, 6.00 mmol) were converted to 341 mg (72%) of the title compound by the procedure of Example 16. MS(FD) 571(M+). IR (CHCl3) ν max 3300, 2971, 1598, 1249, 1165.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06060488
Source dataset	uspto-grants-2000_05
ORD ID	ord-02f9cb12ed834061bf795e5239067f96
Source note	uspto-grants-2000_05