HCID 18785536, compound → HCID 139844130, compound

HRID 1107700Notes

Reaction equation

HRID 1107700 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:36]/[O:37][CH2:38][CH2:39][F:40])/[C:8]([NH:10][C@@H:11]2[C:34](=[O:35])[N:13]3[C:14]([C:22]([O:24]CC4C=CC(OC)=CC=4)=[O:23])=[C:15](/[CH:18]=[CH:19]/[CH2:20]I)[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1.[CH3:41][N:42]([CH2:44][C:45]1[S:49][CH:48]=[N:47][C:46]=1[CH3:50])[CH3:43]>>[NH2:1][C:2]1[S:6][N:5]=[C:4](/[C:7](=[N:36]/[O:37][CH2:38][CH2:39][F:40])/[C:8]([NH:10][C@@H:11]2[C:34](=[O:35])[N:13]3[C:14]([C:22]([O-:24])=[O:23])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:42]([CH3:43])([CH3:41])[CH2:44][C:45]4[S:49][CH:48]=[N:47][C:46]=4[CH3:50])[CH2:16][S:17][C@H:12]23)=[O:9])[N:3]=1

Participants

3

Reactant 2

HCID 18785536HCID 18785536, compoundHCID 139844127HCID 139844127, compound

Product 1

HCID 139844130HCID 139844130, compoundYield 34.5%

Procedure

p-methoxybenzyl 7β[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoroethoxyiminoacetamido]-3-[(E)-3-iodo-1-propen-1-yl]3-cephem-4-carboxylate(1.1 g) and 5-dimethylaminomethyl-4-methylthiazol (0.36 g) were reacted in the same manner as discribed in Example 13 to obtain the target product(330 mg).

Sources & evidence

ORD record
ord-82d9197dba6d48c28e45ad2dfbb5b292
Source dataset
uspto-grants-2000_05
Patent number
US06063778

Reaction notes

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