Ammonia → HCID 18785858, compound

Participants

Reaction Steps

A mixture of 1-ethylthio-3,4-dihydro-3-methylisoquinoline (M. Gittos et al, J. Chem. Soc., Perkin I, 1976, 33) (0.68 g, 3.3 mmol), ammonium iodide (0.48 g, 3.3 mmol) and ammonia (2M in methanol, 4 ml) in ethanol (4 ml) was heated at reflux for 4 h. The mixture was allowed to cool and diethyl ether (100 ml) was added. Some dark oil which separated on standing was decanted and the remaining clear solution stood at -20 ° for 24 h. The resulting crystals were collected, washed with diethyl ether and dried to afford the product as pale yellow prisms (370 mg), m.p. 114-116° C.

Provenance & Evidence