Phosphoric Acid → HCID 70275165, compound

Participants

Reaction Steps

To a stirred solution of phosphoric acid (205 g) at 175° C. was added dropwise 2-(2-thienyl)ethylisothiocyanate (R. V. Davies et al., J. Chem. Soc., Perkin l, 1976, 138). The solution was stirred for 1 h, poured onto ice/water (3 L), the mixture stirred for 3 h to decompose the phosphoric acid, extracted with chloroform, dried over magnesium sulphate and evaporated to give a dark oil which solidified on standing. This solid was taken up in acetone (250 ml) and iodomethane (12 ml) was added. The reaction mixture was stirred for 4 h and the solid was collected to give the title compound as a yellow solid (26 g), m.p. 184-187° C.

Provenance & Evidence