4-Fluorobenzylic alcohol → HCID 53708433, compound

HRID 1107755Notes

Reaction equation

HRID 1107755 reaction equation
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH:14]=[CH:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:7]=12.[F:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][OH:28])=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:30]=[CH:29][C:26]([CH2:27][O:28][C:2]2[N:3]=[N:4][CH:5]=[C:6]3[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH:14]=[CH:15][C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[C:7]=23)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 680224-Fluorobenzylic alcoholHCID 54156760HCID 54156760, compound

Product 1

HCID 53708433HCID 53708433, compoundYield 47.7%

Procedure

The title compound (trans) was prepared as pale yellow crystals in 47.7% yield in a similar procedure to that described in Example 1 by using 7-chloro-2,3-dimethyl-1-(3-phenyl-2-propenyl)pyrrolo[2,3-d]pyridazine (trans) and 4-fluorobenzyl alcohol.

Sources & evidence

ORD record
ord-4481dc11014c46eb897485199b031748
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

Loading…