4-(Trifluoromethyl)benzenemethanol → HCID 18785645, compound

HRID 1107756Notes

Reaction equation

HRID 1107756 reaction equation
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[N:8]([CH2:13][CH:14]=[CH2:15])[C:7]=12.[F:16][C:17]([F:27])([F:26])[C:18]1[CH:25]=[CH:24][C:21]([CH2:22][OH:23])=[CH:20][CH:19]=1>>[CH3:12][C:9]1[N:8]([CH2:13][CH:14]=[CH2:15])[C:7]2=[C:2]([O:23][CH2:22][C:21]3[CH:20]=[CH:19][C:18]([C:17]([F:16])([F:26])[F:27])=[CH:25][CH:24]=3)[N:3]=[N:4][CH:5]=[C:6]2[C:10]=1[CH3:11]

Participants

3

Reactant 2

HCID 676844-(Trifluoromethyl)benzenemethanolHCID 18785586HCID 18785586, compound

Product 1

HCID 18785645HCID 18785645, compoundYield 52.5%

Procedure

The title compound was prepared as pale yellow crystals in 52.5% yield in a similar procedure to that described in Example 1 by using 7-chloro-2,3-dimethyl-1-(2-propenyl)pyrrolo[2,3-d]pyridazine and 4-trifluoromethylbenzyl alcohol.

Sources & evidence

ORD record
ord-a191b1f8aa314ccbab3109a0c1a80a1d
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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