4-Fluorobenzylic alcohol → HCID 54031582, compound

HRID 1107763Notes

Reaction equation

HRID 1107763 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH2:16][CH3:17])[CH:2]=[CH:3][CH3:4].[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][OH:24])=[CH:21][CH:20]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:24][CH2:23][C:22]3[CH:25]=[CH:26][C:19]([F:18])=[CH:20][CH:21]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH2:16][CH3:17])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 680224-Fluorobenzylic alcoholHCID 54507068HCID 54507068, compound

Product 1

HCID 54031582HCID 54031582, compoundYield 41.7%

Procedure

The title compound (trans) was prepared as a white powder in 41.7% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2-ethyl-3-methylpyrrolo[2,3-d]pyridazine (cis/trans=4/96) and 4-fluorobenzyl alcohol.

Sources & evidence

ORD record
ord-7087b13284824448a761fdace59f7b32
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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