3,5-Difluorobenzyl alcohol → HCID 53853750, compound

HRID 1107767Notes

Reaction equation

HRID 1107767 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[F:17][C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([F:26])[CH:25]=1)[CH2:21][OH:22]>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:22][CH2:21][C:20]3[CH:19]=[C:18]([F:17])[CH:25]=[C:24]([F:26])[CH:23]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 5227213,5-Difluorobenzyl alcoholHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 53853750HCID 53853750, compoundYield 41.6%

Procedure

The title compound (cis/trans=29/71) was prepared as a white powder in 41.6% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=24/76) and 3,5-difluorobenzyl alcohol.

Sources & evidence

ORD record
ord-dc6422d7581243c2adcb1c1229bdd819
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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