Propargyl bromide → HCID 18785609, compound

HRID 1107770Notes

Reaction equation

HRID 1107770 reaction equation
[CH2:1]([O:8][C:9]1[N:10]=[N:11][CH:12]=[C:13]2[C:17]([CH3:18])=[C:16]([CH3:19])[NH:15][C:14]=12)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:21][C:22]#[CH:23]>>[CH2:1]([O:8][C:9]1[N:10]=[N:11][CH:12]=[C:13]2[C:17]([CH3:18])=[C:16]([CH3:19])[N:15]([CH2:23][C:22]#[CH:21])[C:14]=12)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 7842Propargyl bromideHCID 187856837-Benzyloxy-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 18785609HCID 18785609, compoundYield 27.4%

Procedure

The title compound was prepared as a pale yellow powder in 27.40% yield in a similar procedure to that described in Example 41 by using 7-benzyloxy-2,3-dimethylpyrrolo[2,3-d]pyridazine and 3-bromo-1-propyne.

Sources & evidence

ORD record
ord-48ee88280d504d27a958ada132380c31
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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