p-Fluorotoluene-alpha-thiol → HCID 53852550, compound

HRID 1107778Notes

Reaction equation

HRID 1107778 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[F:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][SH:25])=[CH:20][CH:19]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([S:25][CH2:24][C:21]3[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 85171p-Fluorotoluene-alpha-thiolHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 53852550HCID 53852550, compoundYield 64.9%

Procedure

The title compound (cis/trans=20:80) was prepared as a pale yellow powder in 64.9% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=23/77) and 4-fluorophenylmethanethiol.

Sources & evidence

ORD record
ord-0b9f4ee6e73b4bcd945bf718492c8619
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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