2,4-Dichlorobenzenemethanethiol → 1-(2-Butenyl)-7-(2,4-dichlorobenzylthio)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107781Notes

Reaction equation

HRID 1107781 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[CH2:25][SH:26]>>[CH2:1]([N:5]1[C:9]2=[C:10]([S:26][CH2:25][C:19]3[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:18]=3[Cl:17])[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 957562,4-DichlorobenzenemethanethiolHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 701042321-(2-Butenyl)-7-(2,4-dichlorobenzylthio)-2,3-dimethylpyrrolo[2,3-d]pyridazineYield 63.2%

Procedure

The title compound (cis/trans=16:84) was prepared as pale brown crystals in 63.2% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=22/78) and 2,4-dichlorophenylmethanethiol.

Sources & evidence

ORD record
ord-39dae1767d2849cbadb275106f2a1f72
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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