4-Fluorobenzylic alcohol → HCID 70105155, compound

HRID 1107787Notes

Reaction equation

HRID 1107787 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[C:6]1[CH3:20])[CH:2]=[CH:3][CH3:4].[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][OH:27])=[CH:24][CH:23]=1>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:27][CH2:26][C:25]3[CH:28]=[CH:29][C:22]([F:21])=[CH:23][CH:24]=3)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[C:6]1[CH3:20])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 680224-Fluorobenzylic alcoholHCID 54470486HCID 54470486, compound

Product 1

HCID 70105155HCID 70105155, compoundYield 49.8%

Procedure

The title compound (cis/trans=14/86) was prepared as a white powder in 49.8% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2-methyl-3-pentylpyrrolo[2,3-d]pyridazine (cis/trans=20/80) and 4-fluorobenzyl alcohol.

Sources & evidence

ORD record
ord-b99980122c514ae2a2842f22a9143cbd
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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