4-Fluorobenzylic alcohol → HCID 18785739, compound

HRID 1107817Notes

Reaction equation

HRID 1107817 reaction equation
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]2[C:10]([CH3:11])=[C:9]([CH3:12])[NH:8][C:7]=12.[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][OH:19])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][O:19][C:2]2[N:3]=[N:4][CH:5]=[C:6]3[C:10]([CH3:11])=[C:9]([CH3:12])[NH:8][C:7]=23)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 680224-Fluorobenzylic alcoholHCID 18785595HCID 18785595, compound

Product 1

HCID 18785739HCID 18785739, compoundYield 29.8%

Procedure

The title compound was prepared as pale yellow crystals in 29.8% yield in a similar procedure to that described in Referential Example 79 by using 7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine and 4-fluorobenzyl alcohol.

Sources & evidence

ORD record
ord-ef666600f4834425a383076bda53f01a
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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