HCID 18785698, compound → HCID 18785633, compound

HRID 1107820Notes

Reaction equation

HRID 1107820 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([C:12]2[NH:16][C:15]([CH3:17])=[C:14]([CH3:18])[CH:13]=2)=[O:11])=[CH:4][CH:3]=1.[CH3:19][CH:20]1[CH2:22][CH:21]1[CH2:23]Br>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([C:12]2[N:16]([CH2:19][CH:20]3[CH2:22][CH:21]3[CH3:23])[C:15]([CH3:17])=[C:14]([CH3:18])[CH:13]=2)=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 18785698HCID 18785698, compoundHCID 21891724Cyclopropane, 1-(bromomethyl)-2-methyl-

Product 1

HCID 18785633HCID 18785633, compoundYield 74.2%

Procedure

The title compound was prepared as a pale yellow oil in 74.20% yield in a similar procedure to that described in Referential Example 97 by using 5-[3-(4-fluorophenyl)propionyl]-2,3-dimethylpyrrole and 2-methylcyclopropylmethyl bromide.

Sources & evidence

ORD record
ord-81d7f5c183b3490ab51360ec83f1220e
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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