2-Butene, 1-bromo- → HCID 53984774, compound

HRID 1107827Notes

Reaction equation

HRID 1107827 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([C:13]1[NH:17][C:16]([CH3:18])=[C:15]([CH3:19])[CH:14]=1)=[O:12].Br[CH2:21][CH:22]=[CH:23][CH3:24]>>[CH2:21]([N:17]1[C:13]([C:11](=[O:12])[CH2:10][CH2:9][C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:14][C:15]([CH3:19])=[C:16]1[CH3:18])[CH:22]=[CH:23][CH3:24]

Participants

3

Reactant 2

HCID 1224142-Butene, 1-bromo-HCID 18785654HCID 18785654, compound

Product 1

HCID 53984774HCID 53984774, compoundYield 55.4%

Procedure

The title compound (cis/trans=23/77) was prepared as a yellow oil in 55.4% yield in a similar procedure to that described in Referential Example 97 by using 5-[3-(2,4-difluorophenyl)propionyl]-2,3-dimethylpyrrole and 1-bromo-2-butene.

Sources & evidence

ORD record
ord-0afaf4e53ca74cefa19f1ff7217c680c
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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