HCID 18785654, compound → HCID 18785653, compound

HRID 1107828Notes

Reaction equation

HRID 1107828 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([C:13]1[NH:17][C:16]([CH3:18])=[C:15]([CH3:19])[CH:14]=1)=[O:12].[CH3:20][CH:21]1[CH2:23][CH:22]1[CH2:24]Br>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][C:11]([C:13]1[N:17]([CH2:20][CH:21]2[CH2:23][CH:22]2[CH3:24])[C:16]([CH3:18])=[C:15]([CH3:19])[CH:14]=1)=[O:12]

Participants

3

Reactant 2

HCID 18785654HCID 18785654, compoundHCID 21891724Cyclopropane, 1-(bromomethyl)-2-methyl-

Product 1

HCID 18785653HCID 18785653, compoundYield 80.2%

Procedure

The title compound was prepared as a yellow oil in 80.2% yield in a similar procedure to that described in Referential Example 97 by using 5-[3-(2,4-difluorophenyl)propionyl]-2,3-dimethylpyrrole and 2-methylcyclopropylmethyl bromide.

Sources & evidence

ORD record
ord-d302945bed984dc8939cee0ce2b883bb
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Reaction notes

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