Diethylamine → HCID 21968634, compound

Participants

Reaction Steps

15 g (41.65 mmol) of (+)-2,3-dimethyl-7-(2-para-methylphenylsulphonyl-1(S)-hydroxyethyl)benzofuran and 210 ml (2.03 mol) of diethylamine are introduced into a 500 ml three-necked flask equipped with a stirrer and a reflux condenser. The solution is stirred at reflux for 16 h and the solution is concentrated. The residue is purified by successive column chromatography operations (elution solvent: 90/10 dichloromethane/methanol) and dried in a desiccator under vacuum over phosphorus pentoxide. 57.4 g of (+)-2,3-dimethyl-7-(2-diethylamino-1(S)-hydroxyethyl)benzofuran are obtained in the wax form -[α]D20 =+94.7° (c=1, methanol). The enantiomeric excess is 98.5%.

Provenance & Evidence