Trifluoroacetic acid → HCID 18786114, compound

Participants

Reaction Steps

180 mg (0.53 mmol) of 2-ethyl-3-phenyl-7-(2-diethylamino-1-hydroxyethyl)benzofuran, 1 ml of triethylsilane and 1 ml of trifluoroacetic acid are introduced into a 25 ml three-necked flask equipped with a reflux condenser. The mixture is stirred for 2 hours at room temperature and then 2 ml of triethylsilane and 1 ml of trifluoroacetic acid are added. The mixture is heated at 70° C. for 48 hours. Potassium carbonate and ethyl ether (30 ml) are added and the mixture is filtered. The filtrate is concentrated under vacuum and the residue is purified by silica column chromatography (elution solvent: 5% methanol in dichloromethane). 80 mg of 2-ethyl-3-phenyl-7-(2-(diethylamino)ethyl)benzofuran are obtained in the form of a wax.

Provenance & Evidence