HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Trimethylsilyloxy-4-(4-(methylthio)phenyl)-3,4-dihydrofuran → 4-(4-(methylthio)phenyl)-2-(5H)-furanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Trimethylsilyloxy-4-(4-(methylthio)phenyl)-3,4-dihydrofuran | HCID 18400192 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(4-(methylthio)phenyl)-2-(5H)-furanone | HCID 12150589 | — |
Reaction Steps
To a solution of 4 g of Pd(OAc)2 in 100 mL of acetonitrile is added dropwise the crude product from Step 1(5 g) under nitrogen at r.t. After 10 h at r.t., the mixture is concentrated under reduced pressure and the residue is purified by flash chromatography on silica gel eluted with 2:1 hexane/EtOAc to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06063811 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-d596ecade25d40b7998be25d27ed4c60 |
| Source note | uspto-grants-2000_05 |