4-Cyanobenzoic acid → HCID 21968624, compound

Participants

Reaction Steps

By following a procedure analogous to Example 5, starting from 4-cyanobenzoic acid and 1-[[3-[(2-methylquinolin-8-yl)oxymethyl]-2,4-dichlorophenyl]sulfonyl]-N-[3-aminopropyl]-2(S)-pyrrolidinecarboxamide hydrochloride, the expected product (yield=75%) is obtained after purification by chromatography on silica gel using a dichloromethane/methanol mixture (98/2; v/v) as the eluent. M.p.=78-80° C. [α]D24 =-39° (c=0.3; CH3OH)

Provenance & Evidence