Triethylamine → 4'-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl][1,1'-biphenyl]-4-carbonyl chloride

Participants

Reaction Steps

A solution of 1.67 g (6.0 mmol) of 11 in 65 mL of dry THF was treated with 710 mg (6.17 mmol) of N-hydroxysuccinimide, followed by 0.835 mL (6.0 mmol) of triethylamine. The reaction was stirred at room temperature for 2 hours after which time it was filtered to remove triethylamine HCl. The filtrate was concentrated at reduced pressure to yield 2.0 g (93%) of 12 as a pale yellow solid.

Provenance & Evidence