反应详情

A round bottom flask was charged with unpurified paroxetine base (8.6 g) in toluene (20 ml) which had been prepared by potassium hydroxide hydrolysis of a phenylcarbamate derivative, and a solution of methanesulfonic acid (1.9 ml) in toluene (10 ml) was added dropwise. The resulting clear solution was placed into a separating funnel and extracted with water (30 ml). The aqueous phase was separated, residual toluene removed by evaporation at reduced pressure and the remaining clear solution (25 ml) was further diluted with water (40 ml). The water was removed by freeze drying to afford amorphous paroxetine methanesulfonate.

1. customThe resulting clear solution was placed into a separating funnel
2. extractionextracted with water (30 ml)
3. customThe aqueous phase was separated
4. customresidual toluene removed by evaporation at reduced pressure
5. additionthe remaining clear solution (25 ml) was further diluted with water (40 ml)
6. customThe water was removed by freeze
7. customdrying