HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2-Acetoxyethyl)thio-2',4'-difluoroacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethanol, 2-mercapto-, 1-acetate | HCID 98505 | — |
| Reactant | 2-Chloro-1-(2,4-difluorophenyl)ethanone | HCID 588083 | — |
| Product | 2-(2-Acetoxyethyl)thio-2',4'-difluoroacetophenone | HCID 10659915 | 65.6% |
Reaction Steps
Using 2-chloro-2',4'-difluoroacetophenone (2.0 g, 0.010 mol), 2-acetoxyethanethiol (J. Chem. Soc., 1952, 817.) (1.5 g, 0.013 mol), potassium carbonate (1.8 g, 0.013 mol) and methanol (50 mol), 2-(2-acetoxyethyl)thio-2',4'-difluoroacetophenone (1.8 g, yield: 62.0%) was obtained as a colorless oil by similar procedures to Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06063945 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-52f2747fa930491da19a9c6a8a70828a |
| Source note | uspto-grants-2000_05 |