HCID 11339601, compound → Ethyl 1-[3-fluoro-5-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxylate

HRID 1108060Notes

Reaction equation

HRID 1108060 reaction equation
FC1C=C(O)C=C(C2(C(OCC)=O)CCCC2)C=1.[F:19][C:20]1[CH:21]=[C:22]([O:37][CH2:38][C:39]2[CH:44]=[CH:43][C:42]([N:45]3[CH:49]=[CH:48][N:47]=[C:46]3[CH3:50])=[CH:41][CH:40]=2)[CH:23]=[C:24]([C:26]2([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:31][CH2:30]O[CH2:28][CH2:27]2)[CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([O:37][CH2:38][C:39]2[CH:44]=[CH:43][C:42]([N:45]3[CH:49]=[CH:48][N:47]=[C:46]3[CH3:50])=[CH:41][CH:40]=2)[CH:23]=[C:24]([C:26]2([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:31][CH2:30][CH2:28][CH2:27]2)[CH:25]=1

Participants

3

Reactant 2

HCID 11339601HCID 11339601, compoundHCID 18786358Ethyl 1-(5-fluoro-3-hydroxyphenyl)cyclopentane-1-carboxylate

Product 1

HCID 18786351Ethyl 1-[3-fluoro-5-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxylate

Procedure

The titled compound was prepared from ethyl 1-(5-fluoro-3-hydroxyphenyl)-cyclopentane-1-carboxylate according to the preparation of ethyl 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate (Example 2).

Sources & evidence

ORD record
ord-72d2d2c93cc14c058984f76c6978f371
Source dataset
uspto-grants-2000_05
Patent number
US06063928

Reaction notes

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