Thionyl Chloride → 4-(2-Methylimidazol-1-yl)benzyl chloride hydrochloride

HRID 1108064Notes

Reaction equation

HRID 1108064 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:14]=[CH:13][C:10]([CH2:11]O)=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.O=S(Cl)[Cl:17]>>[ClH:17].[CH3:1][C:2]1[N:3]([C:7]2[CH:14]=[CH:13][C:10]([CH2:11][Cl:17])=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 11735617[4-(2-Methylimidazol-1-yl)phenyl]methanol

Product 1

HCID 187863424-(2-Methylimidazol-1-yl)benzyl chloride hydrochloride

Procedure

4-(2-Methylimidazol-1-yl)benzyl alcohol (1.28 g, 6.8 mmol) in SOCl2 (5 ml) was stirred at ambient temperature for 30 minutes and then volatiles removed under reduced pressure. The resultant crude product was washed with minimal dry Et2O and dried in vacuo to afford the titled compound (1.65 g, quant.) as white solids.

Workup

  1. customvolatiles removed under reduced pressure
  2. washThe resultant crude product was washed with minimal dry Et2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-300d3ff7a9a0404a91d2485cacc75b1c
Source dataset
uspto-grants-2000_05
Patent number
US06063928

Reaction notes

Loading…