1,5-Dibromopentane → Ethyl 1-(3-benzyloxy-5-fluorophenyl)cyclohexane-1-carboxylate

HRID 1108081Notes

Reaction equation

HRID 1108081 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:12]=[C:13]([F:15])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]Br>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]2([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[CH:12]=[C:13]([F:15])[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 81001,5-DibromopentaneHCID 18786372Ethyl 3-benzyloxy-5-fluorophenylacetate

Product 1

HCID 18786379Ethyl 1-(3-benzyloxy-5-fluorophenyl)cyclohexane-1-carboxylate

Procedure

The titled compound was prepared from ethyl 3-benzyloxy-5-fluorophenylacetate according to the procedure described in Example 2F except that 1,5-dibromopentane was used in place of bis(2-chloroethyl) ether.

Sources & evidence

ORD record
ord-81de5f774a444326bc2e0643f073ad93
Source dataset
uspto-grants-2000_05
Patent number
US06063928

Reaction notes

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