1-(3-Hydroxyphenyl)cyclopentane-1-carboxamide → 1-[3-[4-(2-Methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxamide

HRID 1108086Notes

Reaction equation

HRID 1108086 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2([C:13]([NH2:15])=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl.[CH3:17][C:18]1[N:19]([C:23]2[CH:30]=[CH:29][C:26]([CH2:27]Cl)=[CH:25][CH:24]=2)[CH:20]=[CH:21][N:22]=1>>[CH3:17][C:18]1[N:19]([C:23]2[CH:30]=[CH:29][C:26]([CH2:27][O:1][C:2]3[CH:3]=[C:4]([C:8]4([C:13]([NH2:15])=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]4)[CH:5]=[CH:6][CH:7]=3)=[CH:25][CH:24]=2)[CH:20]=[CH:21][N:22]=1

Participants

3

Reactant 2

HCID 187863211-(3-Hydroxyphenyl)cyclopentane-1-carboxamideHCID 187863424-(2-Methylimidazol-1-yl)benzyl chloride hydrochloride

Product 1

HCID 153921301-[3-[4-(2-Methylimidazol-1-yl)benzyloxy]phenyl]cyclopentane-1-carboxamide

Procedure

1-(3-Hydroxyphenyl)cyclopentane-1-carboxamide was reacted with 4-(2-methyl-imidazol-1-yl)benzyl chloride hydrochloride according to the procedure described in Example 2H to give the titled compound. mp: 163.0-164.0° C.

Sources & evidence

ORD record
ord-75a11baba32f44319043fa8434699d63
Source dataset
uspto-grants-2000_05
Patent number
US06063928

Reaction notes

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