HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran → 4-Cyano-4-[3-[4-(3,5-dimethylpyrazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran | HCID 11360872 | — |
| Reactant | 4-(3,5-Dimethylpyrazol-1-yl)phenyl iodide | HCID 18786313 | — |
| Reactant | (2SR,4RS)-4-cyano-2-methyl-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran | HCID 18786333 | — |
| Reactant | (2SR,4RS)-4-cyano-2-methyl-4-[3-[4-(2-methylimidazol-1-yl) phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran | HCID 18786347 | — |
| Product | 4-Cyano-4-[3-[4-(3,5-dimethylpyrazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran | HCID 18786317 | — |
Reaction Steps
The titled compound was prepared according to the procedure described in example 29E for the preparation of (2SR,4RS)-4-cyano-2-methyl-4-[3-[4-(2-methylimidazol-1-yl) phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran using 4-(3,5-dimethylpyrazol-1-yl)phenyl iodide and 4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran in place of 4-(2-methylimidazol-1-yl)phenyl iodide and (2SR,4RS)-4-cyano-2-methyl-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06063928 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-9044572344b147d9b45c94d22158b026 |
| Source note | uspto-grants-2000_05 |