Acetic Acid → HCID 53785838, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.60 g of (S)-S-[4'-[2-(2,6-difluorophenyl)-4,5-dihydro-4-oxazolyl][1,1'-biphenyl]-4-yl] dimethylcarbamothioate, 5 mL of methanol, and 0.30 g of 25% NaOMe solution was heated at 60° C. for 7 h and allowed to stand at ambient temperature for 3 d. After adding 0.5 mL of acetic acid and 5 mL of water, the product was filtered, washed with water, and suction-dried to afford 0.30 g of product, m.p. 133-135° C. The 1H NMR (CDCl3) spectrum was the same as that of the racemic product of Example 5.

Provenance & Evidence