HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[(tert-Butoxycarbonyl)methyl]-Nalpha-benzyloxycarbonyl-D-tryptophan → 1-[(tert-Butoxycarbonyl)methyl]-D-tryptophan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[(tert-Butoxycarbonyl)methyl]-Nalpha-benzyloxycarbonyl-D-tryptophan | HCID 53803210 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[(tert-Butoxycarbonyl)methyl]-D-tryptophan | HCID 54107619 | 90.9% |
Reaction Steps
The 136 g of product obtained in Step A are diluted with 1.5 liters of methanol and hydrogenated in the presence of 5 g of 10% Pd/C under an H2 pressure of 1.2 bars. After 12 hours of reaction at ambient temperature, the solution is filtered and then concentrated in vacuo. 87 g of the expected product are obtained in the form of a beige powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06066633 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-2f6baca858304bb2ae1a0e355888bf21 |
| Source note | uspto-grants-2000_05 |