Sodium Nitrite → HCID 18432845, compound

HRID 1108222Notes

Reaction equation

HRID 1108222 reaction equation
[N:1]([O-:3])=O.[Na+].[CH:5]1([O:10][C:11]2[CH:12]=[C:13]([CH:24]=[CH:25][C:26]=2[O:27][CH3:28])[CH2:14][N:15]2[C:22]([NH2:23])=[CH:21][C:19](=[O:20])[NH:18][C:16]2=[O:17])[CH2:9][CH2:8][CH2:7][CH2:6]1>C(O)(=O)C>[NH2:23][C:22]1[N:15]([CH2:14][C:13]2[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:11]([O:10][CH:5]3[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH:12]=2)[C:16](=[O:17])[NH:18][C:19](=[O:20])[C:21]=1[N:1]=[O:3]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 54079322HCID 54079322, compound

Product 1

HCID 18432845HCID 18432845, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

15.81 nil of 4N sodium nitrite solution was added dropwise at 65°-70° C. over 8 minutes to a solution of 20.53 g of 1-(3-cyclopentyloxy-4-methoxy-benzyl) 6-amino uracil in 300 ml of acetic acid. After 30 minutes the suspension was cooled to room temperature and the solid collected and washed with water to give the title compound (19.36 g) as pink crystals. The filtrate was evaporated to dryness, the residue suspended in 100 ml of water and the solid collected to give 1.98 g as a second crop.

Workup

  1. customthe solid collected
  2. washwashed with water

Sources & evidence

ORD record
ord-c15c30b8f8c64786b4f1f4667036bfa2
Source dataset
uspto-grants-2000_05
Patent number
US06066641

Reaction notes

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