6-Amino-1-(4-chloro-benzyl)-1H-pyrimidine-2,4-dione → 6-Amino-1-[(4-chlorophenyl)methyl]-5-nitroso-2,4(1H,3H)-pyrimidinedione

Participants

Reaction Conditions

Reaction Steps

157.6 ml of 4N sodium nitrite was added over 45 minutes to a suspension of 165 g of 6-amino-1-(4-chlorobenzyl)-uracil in 825 ml of acetic acid at 65-70° C. After a further 15 minutes at 70° C. the reaction mixture was cooled to room temperature, the pink solid collected and washed with 80% acetic acid and water to give the title compound (150.9 g) mp >320° C.

Provenance & Evidence