Methyl iodide → 2-(Methylthio)-3-propylthieno[3,2-d]pyrimidin-4(3H)-one

Participants

Reaction Conditions

Reaction Steps

To a mixture containing 3.6 g of the title compound of Step A suspended in 70 mL of 10% propanolic sodium hydroxide was added 1.46 mL of iodomethane with stirring. The mixture was stirred at room temperature for 1 h, then cooled to 0° C. and filtered to obtain an off-white solid. The off-white solid was purified by partially dissolving it in methylene chloride, filtering and evaporating the filtrate to obtain 3.13 g of the title compound of Step B as a white solid melting at 136-138° C.

Provenance & Evidence