Sodium Hydroxide → HCID 178508890, compound

Participants

Reaction Steps

Upon saponification of methyl 5-[2-(2-pivaloylamino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]pyrrole-3-carboxylate (401 mg g, 1.0 mmol) with 1N sodium hydroxide (15 mL) as described in Example 11, there is obtained 5-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]pyrrole-3-carboxylic acid, mp >260° C.: 1H NMR (DMSO-d6) δ 11.49 (s, 1H), 10.12 (br s, 1H), 9.66 (s, 1H), 7.16 (s, 1H), 6.23 (s, 1H), 6.05 (s, 2H), 5.90 (s, 1H), 3.16 (brd, 1H, J=10.9 Hz), 2.78 (m, 1H), 2.63-2.40 (m, 2H), 1.77 (dd, 1H, J=15.2, 8.6 Hz), 1.69-1.43 (m, 3H).

Provenance & Evidence