Water → HCID 18784870, compound

HRID 1108301Notes

Reaction equation

HRID 1108301 reaction equation
[OH:1]OS([O-])=O.[K+].[CH3:7][O:8][C:9]1[C:17]2[O:16][C:15]([S:18][CH3:19])=[CH:14][C:13]=2[CH:12]=[CH:11][CH:10]=1.[OH2:20]>>[CH3:19][S:18]([C:15]1[O:16][C:17]2[C:9]([O:8][CH3:7])=[CH:10][CH:11]=[CH:12][C:13]=2[CH:14]=1)(=[O:1])=[O:20]

Participants

4

Reactant 3

HCID 962WaterHCID 18784863HCID 18784863, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 18784870HCID 18784870, compound

Procedure

A solution of Oxone® (7.37 g) in water (40 ml) was added to a solution of 7-methoxy-2-methylsulfanylbenzofuran (2.24 g) and the reaction mixture was stirred at room temperature overnight. The methanol was removed in vacuo and the resulting slurry was extracted with ethyl acetate (2×200 ml). The combined organic phases were washed with brine (200 ml) and then dried over sodium sulfate. The solvent was removed in vacuo to furnish the title compound as a yellow solid (2.24 g).

Workup

  1. customThe methanol was removed in vacuo
  2. extractionthe resulting slurry was extracted with ethyl acetate (2×200 ml)
  3. washThe combined organic phases were washed with brine (200 ml)
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-39ba42ff805349f483983f04bf9a52f1
Source dataset
uspto-grants-2000_05
Patent number
US06066657

Reaction notes

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