N-bromobutanimide → HCID 18784861, compound

HRID 1108306Notes

Reaction equation

HRID 1108306 reaction equation
[CH3:1][S:2]([C:5]1[O:6][C:7]2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)(=[O:4])=[O:3].[Br:16]N1C(=O)CCC1=O>C(#N)C>[Br:16][C:10]1[C:8]2[CH:9]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[O:6][C:7]=2[C:13]([O:14][CH3:15])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 18784870HCID 18784870, compound

Product 1

HCID 18784861HCID 18784861, compoundYield 109.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 2-methanesulfonyl-7-methoxybenzofuran (0.50 g) and N-bromosuccinimide (0.39 g) in acetonitrile (30 ml). Purification by flash chromatography on silica eluting with 50% ethyl acetate in hexane gave the title compound as a white solid (0.73 g).

Workup

  1. customPurification by flash chromatography on silica eluting with 50% ethyl acetate in hexane

Sources & evidence

ORD record
ord-529ed58cc0254514b83c8c638b0b6dc9
Source dataset
uspto-grants-2000_05
Patent number
US06066657

Reaction notes

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