HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(Cyclopropyl-methoxy-methyl)-7-methoxybenzofuran-4-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Bromo-2-(cyclopropyl-methoxy-methyl)-7-methoxybenzofuran | HCID 18784865 | — |
| Reactant | Oxolane--water (1/1) | HCID 21881883 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | 2-(Cyclopropyl-methoxy-methyl)-7-methoxybenzofuran-4-carboxylic Acid | HCID 18784847 | — |
Reaction Steps
Prepared from 4-bromo-2-(cyclopropyl-methoxy-methyl)-7-methoxy-benzofuran (350 mg), palladium acetate (25 mg), 1,3-(diphenylphosphino)propane (93 mg) and triethylamine (1.6 ml) in tetrahydrofuran/water (20 ml/10 ml). The title compound was obtained as a cream solid (250 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06066657 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-c34d488154e2480186900fc253da716e |
| Source note | uspto-grants-2000_05 |