HCID 21968740, compound → HCID 21968739, compound

Participants

Reaction Steps

A solution of 1.37 g of N2[2(RS)[tert-butoxycarbonylmethyl]-3-cyclobutylpropionyl]-N1,3-dimethyl-L-valinamide as a 1:1 mixture of diastereoisomers in 20 ml of trifluoroacetic acid was stirred at room temperature for 2.5 hours. The solvent was removed by evaporation to leave an oil which was partitioned between diethyl ether and 5% sodium hydrogen carbonate solution. The aqueous phase was acidified with hydrochloric acid and extracted with dichloromethane. The organic layer was dried over anhydrous magnesium sulphate and then evaporated to give 1.2 g of N2-[2(RS)[carboxymethyl]-3-cyclobutylpropionyl]-N1,3-dimethyl-L-valinamide as a 1:1 mixture of diastereoisomers in the form of a white foam.

Provenance & Evidence