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Triphenylphosphine → Methyl 2-ethyl-2-(1-methylethyl)-4-oxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Ozone | HCID 24823 | — |
| 反応物 | HCID 10607559 | HCID 10607559 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 2-ethyl-2-(1-methylethyl)-4-oxobutanoate | HCID 10773902 | — |
反応手順
The reaction of the olefinic ester, methyl 2-ethyl-2-(1-methylethyl)-4-pentenoate (9.20 g, 50 mmol), with ozone in CH2Cl2 (200 mL) at -78° C., followed by the treatment of the resulting ozonide with Ph3P (19.65 g, 75 mmol) as described above in the preparation of Example 7, gave 14.36 g of an oily residue. Flash chromatography over silica gel (hexanes-EtOAc, 9:1) afforded the aldehyde (8.20 g, 88%) as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06066666 |
| 出典データセット | uspto-grants-2000_05 |
| ORD ID | ord-ce573f0c57ca40b09c41fa27e7f27214 |
| 出典メモ | uspto-grants-2000_05 |