Methanol → HCID 53947038, compound

Participants

Reaction Steps

100 mg (0.37 mmol) of 7-amino-3-β-D-ribofuranosyl-(3H)-1,2,3-triazolo[4,5-d]pyrimidine are left to stir overnight, at room temperature, in 2 ml of dry DMF and 0.25 ml (1.85 mmol) of N,N-dimethylformamide dimethyl acetal. 4 ml of methanol is then added to this reaction mixture. After having been stirred for a further 2 hours, the mixture is evaporated to dryness, and the residue is coevaporated with toluene and then chromatographed on silica gel. (Column: 3×20 cm, eluent CH2Cl2 /MeOH 98:2-90:10). 0.06 g (52%) of a colorless, glassy solidified substance is obtained in the main zone. TLC (silica gel, CH2Cl2 /MeOH=9:1): Rf =0.25 UV λmax (ε)=235, 325.

Provenance & Evidence