HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1108449Generated: October 25, 2026
Ammonia → 3-Methoxy-5-methylpyrazine-2-carboxamide
https://huagongshe.com/reaction/1108449
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 3-methoxy-5-methylpyrazine-2-carboxylate | HCID 21702987 | — |
| Product | 3-Methoxy-5-methylpyrazine-2-carboxamide | HCID 11062776 | 87% |
Reaction Steps
1 g (5.5 mmol) of methyl 3-methoxy-5-methylpyrazine-carboxylate was initially charged in 15 ml (198 mmol) of NH3 (25%) and the mixture was stirred at 50° C. After concentration, 0.8 g of 3-methoxy-5-methylpyrazine-2-carboxamide was obtained. The yield was 86 percent. Other data concerning the title product was:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06066736 |
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| Source dataset | uspto-grants-2000_05 |
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| ORD ID | ord-93160725dc4f4913922cf20cc4f7a314 |
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| Source note | uspto-grants-2000_05 |
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