HCID 178418361, compound → HCID 178500031, compound

HRID 1108504Notes

Reaction equation

HRID 1108504 reaction equation
[NH:1]1[CH:5]=[C:4]([CH:6]=[CH:7][C:8]([O:10][CH3:11])=[O:9])[N:3]=[CH:2]1.[H][H]>CO.[Pd]>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178500030HCID 178500030, compound

Product 1

HCID 178500031HCID 178500031, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of ester 2 (5.3 g) in methanol at room temperature was added 10% palladium on carbon (20 mg) under a blanket of argon.. A balloon of hydrogen was applied, and the reaction was stirred for one hour. The solution was filtered, and then concentrated in vacuo to dryness to provide the crude product 3 which was sufficiently pure for use in the next step.

Workup

  1. filtrationThe solution was filtered
  2. concentrationconcentrated in vacuo to dryness

Sources & evidence

ORD record
ord-e91f3c56d5fe4df086f6b03d7ca705bd
Source dataset
uspto-grants-2000_05
Patent number
US06066738

Reaction notes

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