Potassium Carbonate → HCID 18784785, compound

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (10.6 g, 76.5 mmol) was added to a solution of Example 2 Part A compound (15.0 g, 69.6 mmol) and 4-fluorobenzaldehyde (Aldrich) (8.61 g, 69.6 mmol) in N,N-dimethylacetamide (100 mL) and the reaction was stirred at 125° C. for 24 h, then cooled to RT. The reaction was dissolved in CH2Cl2 (500 mL) and washed with water (4×180 mL) and brine (2×200 mL), then dried over MgSO4. Evaporation gave a solid mass. The crude product was triturated with EtOAc (10 mL), then washed with EtOAc (10 mL) and filtered to give title compound (17.8 g, 80%) as a white solid (mp 211-214° C.).

Provenance & Evidence