Sodium borohydride → HCID 9884000, compound

Participants

Reaction Steps

(-)-5-Acetamidomethyl-3-(3-fluoro-4-(3-formyl-pyrrol-1-yl)phenyl)isoxazoline (Example 15) (658 mg) is suspended/dissolved in 20 ml methanol under nitrogen. The mixture is treated with sodium borohydride (76 mg) and the reaction is stirred 1 hour at room temperature. The reaction is diluted with 1×10 ml 2N sodium hydroxide and the volatiles are removed in vacuo. The residue is diluted with 20 ml water and the white solid is collected and dried to give 609 mg of the title compound as an off white solid, mp 162-164° C., [α]25D -72° (c 0.54, methanol).

Provenance & Evidence