3-Fluoro-4-(4-ethyl-3-oxopiperazin-1-yl)nitrobenzene → 5-Amino-2-(4-ethyl-3-oxopiperazin-1-yl)fluorobenzene

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Reaction Steps

3-Fluoro-4-(4-ethyl-3-oxopiperazin-1-yl)nitrobenzene (3.4 g) was dissolved in ethyl acetate (200 ml) and the solution flushed with argon. Palladium (10% on carbon, 180 mg) was added, and the mixture hydrogenated under ambient pressure. After gas uptake had ceased, the mixture was filtered through celite and solvent evaporated to give 5-amino-2-(4-ethyl-3-oxopiperazin-1-yl)fluorobenzene, which was used without further purification.

Provenance & Evidence