Ammonia → 1-(3-aminopropyl)-1H-imidazo[4,5-c]quinoline-4-amine

Participants

Reaction Steps

14 mg (0.0536 mmol) of 1-(3-aminopropyl)-4-chloro-1H-imidazo[4,5-c]quinoline, 5 ml of methanol and 3 ml of liquid ammonia were stirred in an autoclave overnight at 150° C. under heating. The reaction mixture was concentrated under reduced pressure and 0.3 ml of a 1N sodium hydroxide solution was added to the residue. The precipitate thus formed was collected by filtration to obtain 8 mg (0.0331 ml) of 1-(3-aminopropyl)-1H-imidazo[4,5-c]quinoline-4-amine shown below. ##STR38## The physicochemical data of this compound was in agreement with the compound of Example 5.

Provenance & Evidence