Ethyl orthoformate → HCID 18783939, compound

Participants

Reaction Conditions

Reaction Steps

0.32 ml (1.92 mmol)of Triethyl ortho-formate was added to 0.14 g (0.384 mmol) of 3-amino-4-[4-(tert-butoxycarbonylamino)butylamino]-2-chloroquinoline. The mixture was heated at 100° C. and stirred overnight. The reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (chloroform:methanol=150:1 to 100:1 (v/v)) to obtain 0.12 g (0.321 mmol) of 1-[4-(tert-butoxycarbonylamino)butyl]-4-chloro-1H-imidazo[4,5-c]quinoline as pale orange powder (mp: 148-150° C.). ##STR43## Its spectroscopic data are as follows: IR (KBr) cm-1 : 1695, 1510.

Provenance & Evidence